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1.
Khirurgiia (Mosk) ; (1): 14-6, 1999.
Artigo em Russo | MEDLINE | ID: mdl-10050503

RESUMO

Data of experimental study in 18 mongrel dogs followed by clinical trial in 96 patients are represented, which concerns a method of indirect medicamentous saturation of lymphatic system, consisted in creation of medicamentous subcutaneous infiltration in the thighs followed by pneumocompression. Gentamycin contents in blood lymphatics and organs of experimental animals was studied in various periods of time. The obtained data have determined identity of the effect with the method of introduction of the antibiotics together with the media, which possess hyaluronidaze-like action, and followed by 2 hours duration phlebohypertension (by V.M.Buyanov, 1991). It promotes reduction of time for the procedure more than 3 times and gives possibility to avoid introduction of additional preparations, which are unnecessary load to the procedure. Gentamycin contents in blood serum of patients in various time intervals are demonstrated.


Assuntos
Gentamicinas/uso terapêutico , Sistema Linfático/efeitos dos fármacos , Adulto , Idoso , Animais , Cães , Sistemas de Liberação de Medicamentos , Seguimentos , Gentamicinas/farmacocinética , Humanos , Injeções Subcutâneas , Linfa/metabolismo , Sistema Linfático/metabolismo , Linfócitos/metabolismo , Pessoa de Meia-Idade , Curativos Oclusivos , Coxa da Perna
2.
Prikl Biokhim Mikrobiol ; 20(3): 369-72, 1984.
Artigo em Russo | MEDLINE | ID: mdl-6540443

RESUMO

The effect of dextranase enzyme preparations obtained from Penicillium piscarium BIM G-102, Penicillium funiculosum, Aspergillus insuetus G-116 and Aspergillus ustus on polysaccharides synthesized by cariesogenic Streptococcus sanguis and Streptococcus mitis was being studied. According to the data obtained dextranases from P. piscarium, P. funiculosum and Asp. ustus can be considered as a promising anticarious agent.


Assuntos
Dextranase/metabolismo , Fungos Mitospóricos/enzimologia , Polissacarídeos Bacterianos/metabolismo , Streptococcus/metabolismo , Aspergillus/enzimologia , Cárie Dentária/tratamento farmacológico , Cárie Dentária/microbiologia , Dextranase/uso terapêutico , Avaliação Pré-Clínica de Medicamentos , Humanos , Hidrólise , Penicillium/enzimologia , Streptococcus sanguis/metabolismo
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